Vitamins >> Vitamin B12 and  Depression

Observational studies have found as many as 30% of patients hospitalized for depression to be deficient in vitamin B₁₂. A recent cross-sectional study of 700 community-living, physically disabled women over the age of 65 found that vitamin B₁₂ deficient women were twice as likely to be severely depressed as non-deficient women.

The reasons for the relationship between vitamin B₁₂ deficiency and depression are not clear. Vitamin B₁₂ and folate are required for the synthesis of S-adenosylmethionine, a methyl group donor essential for the metabolism of neurotransmitters, whose bioavailability has been related to depression. Because few studies have examined the relationship of vitamin B₁₂ status and the development of depression over time, it cannot yet be determined if vitamin B₁₂ deficiency plays a causal role in depression. However, due to the high prevalence of vitamin B₁₂ deficiency in older individuals, it may be beneficial to screen them for vitamin B₁₂ deficiency as part of a medical evaluation for depression.

See also:

• Vitamin B12: Cobalamin Information, Benefits of Vitamin B12

• Vitamin B12 Deficiency: Pernicious anemia

• Vitamin B12: Homocysteine and Cardiovascular Diseases

• Vitamin B12 and Cancer

• Vitamin B12 and Breast Cancer

• Vitamin B12 - Neural tube Defects

• Vitamin B12 - Alzheimer's Disease and Dementia

• Vitamin B12 and Depression

• Vitamin B12 Functions: Cofactor for methionine synthase

• Vitamin B12 - Safety

• Vitamin B12 - Food sources & Supplements

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