Vitamins >> Vitamin B12 and Breast Cancer

A case-control study compared prediagnostic levels of serum folate, vitamin B6, and vitamin B₁₂ in 195 women later diagnosed with breast cancer and 195 age-matched women who were not diagnosed with breast cancer. Among women who were postmenopausal at the time of blood donation, the association between blood levels of vitamin B₁₂ and breast cancer suggested a threshold effect.

The risk of breast cancer was more than doubled in those women with serum vitamin B₁₂ levels in the lowest quintile (1/5) compared to those women in the four highest quintiles.

The investigators found no relationship between breast cancer and serum levels of vitamin B₆, folate, or homocysteine. Because this study was observational, it cannot be determined whether decreased serum levels of vitamin B₁₂ were a cause or a result of breast cancer. Previously, there has been little evidence to suggest a relationship between vitamin B₁₂ status and breast cancer risk. However, the above studies point to a need for further investigation of the relationship between vitamin B₁₂ status and cancer risk.

See also:

• Vitamin B12: Cobalamin Information, Benefits of Vitamin B12

• Vitamin B12 Deficiency: Pernicious anemia

• Vitamin B12: Homocysteine and Cardiovascular Diseases

• Vitamin B12 and Cancer

• Vitamin B12 and Breast Cancer

• Vitamin B12 - Neural tube Defects

• Vitamin B12 - Alzheimer's Disease and Dementia

• Vitamin B12 and Depression

• Vitamin B12 Functions: Cofactor for methionine synthase

• Vitamin B12 - Safety

• Vitamin B12 - Food sources & Supplements

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