Vitamins >> Vitamin B12 - Functions

Cofactor for methionine synthase

Methylcobalamin is required for the function of the folate-dependent enzyme, methionine synthase. This enzyme is required for the synthesis of the amino acid, methionine, from homocysteine. Methionine is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA and RNA. Methylation of DNA may be important in cancer prevention. Inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular diseases.

Cofactor for L-methylmalonyl-CoA mutase

5-Deoxyadenosylcobalamin is required by the enzyme that catalyzes the conversion of L-methylmalonyl-CoA to succinyl-CoA. This biochemical reaction plays an important role in the production of energy from fats and proteins. Succinyl CoA is also required for the synthesis of hemoglobin, the oxygen carrying pigment in red blood cells.

See also:

• Vitamin B12: Cobalamin Information, Benefits of Vitamin B12

• Vitamin B12 Deficiency: Pernicious anemia

• Vitamin B12: Homocysteine and Cardiovascular Diseases

• Vitamin B12 and Cancer

• Vitamin B12 and Breast Cancer

• Vitamin B12 - Neural tube Defects

• Vitamin B12 - Alzheimer's Disease and Dementia

• Vitamin B12 and Depression

• Vitamin B12 Functions: Cofactor for methionine synthase

• Vitamin B12 - Safety

• Vitamin B12 - Food sources & Supplements

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